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Role of Cellular Senescence in Aging; and What We Can Do To Slow It Down

At BioCure Health we are OBSESSED with improving longevity and extending the time that we are healthy, and one aspect that is widely overlooked is cellular senescence.  Cellular Senescence plays a crucial role in the aging process, serving as a double-edged sword in the complex web of biological mechanisms that govern our bodies. Senescence is essentially a state in which cells cease to divide, but remain metabolically active, contributing to tissue repair, wound healing, and even cancer prevention in our younger years. However, as we age, the accumulation of senescent cells becomes a significant contributor to various age-related diseases and the overall decline in our physical functions.  Some people (myself included) refer to these senescent cells as zombie cells.

These senescent cells release a range of bioactive molecules, collectively known as the senescence-associated secretory phenotype (SASP), which can cause inflammation and damage to surrounding tissues. This chronic inflammation and tissue dysfunction can lead to the development of conditions such as arthritis, cardiovascular disease, neurodegenerative diseases, and more. By promoting this proinflammatory environment, senescent cells accelerate the aging process at a cellular level (and at the end of the day, we are simply a sum of all of our cells)

Fortunately, there are various strategies that we recommend to our patients and that you can employ to reduce the burden of cellular senescence and potentially slow down the aging process. One promising approach is the development of senolytic drugs, which specifically target and eliminate senescent cells from the body. These drugs have shown promising results in preclinical studies, demonstrating improvements in a wide range of age-related conditions and extending the healthspan in some experiments.  Our favorite product is by a lab called StrategIQ Health.  The product contains various senolytic compounds; from Quercetin, Fisetin, and others.  Check them out here.

Lifestyle factors such as regular exercise, a healthy diet rich in antioxidants, and adequate sleep play a significant role in reducing cellular senescence. Exercise has been shown to reduce the accumulation of senescent cells in various tissues, while a diet high in colorful fruits and vegetables provides essential nutrients and antioxidants that help combat oxidative stress and inflammation. Adequate sleep is also crucial, as it allows the body to repair and regenerate cells, potentially reducing the burden of senescent cells.

In addition to these lifestyle changes, emerging research suggests that interventions such as intermittent fasting and calorie restriction may also help reduce cellular senescence and promote healthy aging. Most of the Doctors at BioCure Health follow a low-carb, Mediterranean diet, coupled with intermittent fasting.  These dietary interventions have been shown to improve metabolic health, reduce inflammation, and enhance cellular repair mechanisms, all of which can contribute to a reduction in the accumulation of senescent cells.

Overall, while cellular senescence is a natural part of the aging process, understanding its role and implementing strategies to reduce its impact can help us lead healthier and more vibrant lives as we grow older. By embracing a holistic approach that combines senolytic drugs, healthy lifestyle choices, hormone optimization, and dietary interventions, we can work towards mitigating the effects of cellular senescence and promoting healthy aging for years to come.
At BioCure, our slogan is:  Aging…on YOUR terms.  It is up to you to take control of how your body is adapting to changes.  We currently have the technology and science to push back against Father Time, let BioCure Health show you how.  To learn more, Call or Text us at 754-206-0838 to schedule a call with one of our Treatment Coordinators to see how we can help you optimize your overall health and well-being.


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Age Management